Zhang et al, working at Oxford University, have developed a novel deployable microstent for MIGS applications, leveraging deployable structure concepts and biocompatible nitinol to mechanically separate ocular tissues in the subconjunctival space (SCS).
The microstent can be delivered minimally invasively, ab internally via a needle and subsequently expands within the SCS.
This design incorporates structural elements to sustain conjunctival-episcleral separation without relying on anti-fibrosis treatments. It is specifically optimized to form a posterior, consistently elevated bleb while preventing migration, improving durability, and ensuring long-term efficacy.
The device is constructed from nitinol, a biocompatible metal renowned for its proven long-term ocular safety and successful use in larger filtration devices like the EX-PRESS shunt.
The enhanced flexibility allows the stent to conform to surrounding tissues, potentially reducing fibrosis and minimizing patient discomfort.
This microstent consists of a flexible tube that connects the AC to the SCS and a self-expanding element to support a subconjunctival bleb. The expandable element is designed to triple its original size upon deployment, a transformation enabled by the superelasticity of nitinol.
It features four slender struts asymmetrically arranged along the central axis of the flexible tube. After deployment, these struts self-expand to lift the conjunctiva and Tenon’s layer from the sclera, creating a bleb.
Results showed that a 1 mm expandable element can create a spindle-shaped bleb approximately 0.7 mm in radius and 6 mm in length without permanent deformation.
REFERENCE:
A novel deployable microstent for the treatment of glaucoma. Zhang, Yunlan et al. The Innovation, Volume 6, Issue 8, 100935
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