Curcumin has been used in traditional medicine for many years. It's role in ophthalmic diseases has been reviewed in an article recently published by my colleagues and myself.
It is known that reactive oxygen species (ROS) play a role in the development and progression of glaucoma. Yue and colleagues have studied the effect of curcumin as an antioxidant in glaucoma patients.
On the other hand, Lin and colleagues have shown that trabecular meshwork (TM) cells are damaged in glaucoma. Pre-treatment with curcumin protects the TM cells against oxidative stress-induced cell death.
Cheng and colleagues developed a thermosensitive chitosan-gelatin-based hydrogel that contains 20 μm curcumin-loaded nanoparticles and latanoprost. This dual-drug delivery system acts as a sustained-release agent. Curcumin decreases the oxidative stress-mediated damage to the TM cells by reducing inflammation-related gene expression, mitochondrial ROS production, and apoptosis.
Please access the complete article at the following link:
https://www.florajournal.com/archives/
https://www.florajournal.com/archives/2025/vol13issue4/PartC/13-1-32-664.pdf
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