IRIDOCORNEAL ENDOTHELIAL SYNDROMES: A primer

Iridocorneal Endothelial Syndromes (ICE) are characterized by the following:

Common features of the three ICES:

1. Corneal endothelial dystrophy

2. Distorted pupil

3. Ectropion uveae

4. Goniosynechiae

5. Secondary synechial glaucoma

Characteristics which distinguish between the three ICES:

1. Iris naevus syndrome (Cogan-Reese)=

Multiple small or a few larger iris nodules.

2. Chandler’s Syndrome=

Corneal oedema at normal or mildly elevated IOP.

3. Essential iris atrophy=

Progressive iris atrophy with iris hole formation (opposite to the side of goniosynechiae).