OPTIC NERVE HEAD
DEFINITION:
The
optic disc represents the distal portion of the optic nerve and is the point
where the axons of retinal ganglion cells (RGCs) come in close approximation to each other. It
extends anteriorly from the retinal surface to the myelinated portion of the
optic nerve that begins just behind the sclera, posterior to the lamina
cribrosa.
The
term “optic nerve head” is preferable to “optic disc” since the latter term
suggests a flat structure without depth.
ANATOMY:
The
ONH comprises of nerve fibers that originate in the ganglion cell layer of the
retina and converge upon the optic nerve head (ONH) from all over the fundus.
At the surface of the ONH, the axons of the RGC bend acutely to exit the globe
through a fenestrated scleral canal, called the lamina cribrosa.
In
the ONH, the axons are grouped into approximately 1000 fascicles or bundles and
are supported by astrocytes.
The
diameter of the ONH varies with a mean of 1.88 mm vertically and 1.77 mm
horizontally. The disc area varies from 0.68-4.42 mm2.
The
diameter of the optic nerve expands to approximately 3 mm just behind the
sclera, where the neurons acquire a myelin sheath. The ONH is also the site of
entry and exit of the retinal vessels. This vascular system supplies some
branches to the ONH, although the predominant blood supply for the nerve head
comes from ciliary circulation.
DIVISIONS
OF THE ONH:
The
ONH maybe arbitrarily divided into 4 portions from anterior to posterior=
- Surface nerve fiber layer: It is contiguous with the nerve fibre layer of the retina. The innermost portion of the ONH is composed predominantly of nerve fibers. The axonal bundles acquire progressively more interaxonal glial tissue in the intraocular portion of the ONH as the structure is followed posteriorly.
- Prelaminar region: Also known as anterior portion of lamina cribrosa. The predominant structures at this level are nerve axons and astrocytes with a significant increase in the quantity of astroglial tissue. The astroglia form sheaths around each nerve bundle.
- Lamina cribrosa region: This Laminar (Scleral) portion is made up of sheets of connective and elastic tissue, and contains fenestrations which give passage to the nerve fibre bundles and retinal blood vessels. Astrocytes separate the sheets and line the fenestrae, with the fascicles of neurons leaving the eye through the openings. It also serves to maintain intra-ocular pressure (IOP) against a gradient between the intra-ocular and extra-ocular spaces.
- Retrolaminar region: This area is characterized by a decrease in astrocytes and myelinated nerve fibres (acquisition of myelin by oligodndrocytes), circumscribed by leptomeninges of the CNS. The axonal bundles are surrounded by connective tissue septa. The posterior extent of the retrolaminar region is not clearly defined.
VASCULATURE:
The
main source of arterial supply to the ONH is through the posterior ciliary
artery circulation. However, the retinal nerve fiber layer is supplied by
retinal circulation.
The
surface nerve fiber layer is mainly supplied by arteriolar branches of the
central retinal artery which anastomose with vessels of the prelaminar region
and are continuous with the peripapillary retinal and long retinal
peripapillary capillaries. The temporal region may also be supplied by one or
more of the ciliary-derived vessels from the posterior ciliary artery
circulation in the deeper prelaminar region, which may occasionally enlarge to
form cilioretinal arteries. The cilioretinal artery when present, usually
supplies the corresponding sector of the surface layer.
The
prelaminar and laminar regions are supplied primarily by Short Posterior
Ciliary Arteries (SPCA) which form a perineural circular arterial anastomoses
at the scleral level, called the “Circle of Zinn-Haller”. Branches from this
circle penetrate the ON to supply the prelaminar and laminar regions and
peripapillary choroid. The circle is not present in all eyes, in which case
direct branches from the SPCA supply the anterior ON. The peripapillary choroid
may also minimally contribute to the anterior ON.
The
retrolaminar region is supplied by both the ciliary and retinal circulations,
with the former coming from recurrent pial vessels. Medial and lateral peri-optic
nerve SPCAs anastomose to form an elliptical arterial circle around the ON,
which is also referred to as the Circle of Zinn-Haller. The central retinal
artery provides centripetal branches from the pial system and frequently but
not always gives off centrifugal vessels.
CAPILLARIES:
Although
derived from both the retinal and ciliary circulations, the capillaries of the
ONH resemble more closely the features of retinal capillaries than of
choriocapillaries. These characteristics include: tight junctions; abundant
pericytes; nonfenestrated endothelium. They do not leak fluorescein and may
represent a nerve-Blood barrier.
VENOUS
DRAINAGE:
Venous
drainage of the ONH occurs mainly through the central retinal vein, although a
small portion may occur through the choroidal system.
ASTROGLIAL
SUPPORT:
Astrocytes
provide a continuous layer between the nerve fibers and blood vessels in the
ONH. The astrocytes are joined by “gap junctions” which resemble tight
junctions but have minute gaps between the outer membrane leaflets.
Thick
and thin bodied astrocytes have been identified. The thin bodied ones
accompany the axons in the nerve fiber layer and the thick bodied astrocytes
direct axons in the prelaminar region toward the laminar region.
The
astroglial tissue also provides a covering for portions of the ONH. The
internal limiting membrane of Elschnig separates the nerve head from the
vitreous and is continuous with the internal limiting membrane of retina.
The
Muller cells are a major constitutional element of the intermediary tissue of
Kuhnt, which separates the nerve from the retina, whereas the border tissue of
Jacoby separates the nerve from the choroid. Astrocytes also play a role in the
remodeling of the extra cellular matrix of the ONH and synthesizing growth
factors and other cellular mediators that may affect the axons of the RGCs and
contribute to health or susceptibility to disease.
LAMINA
CRIBROSA:
The
Lamina Cribrosa (LC) is a porous region of the sclera with a specialized
extracellular matrix consisting of fenestrated sheets of connective tissue and occasional
elastic fibers lined with astrocytes. Astrocytes may respond to changes in IOP
leading to axonal loss and RGC degeneration at the level of LC. The
extracellular matrix components in the LC are different from those seen in the
sclera or pial septa. The decrease of hyaluronate with ageing, especially in Primary
Open Angle Glaucoma, possibly increases the susceptibility to elevated IOP. The
LC is thinner in glaucomatous eyes compared to normal eyes.
CSLO
of the pores in the LC has shown that in glaucomatous eyes the pores are nearly
circular compared to the compressed pores seen in non-glaucomatous eyes. The
superior and inferior parts of the ON have large single pore areas with thinner
connective tissue and glial cell support. A majority of RGC axons exit through
the LC taking a direct course. However, about 10% of the axons exit more
peripherally, where the LC is more curvilinear, which may influence the
regional susceptibility for glaucomatous optic nerve fiber loss. The size of
the laminar openings for the retinal vessels does not correlate with the LC
area.
The
extracellular matrix in the LC is composed of: Collagen types I-VI, laminin and
fibronectin. The cribriform plates are composed of a core of elastic fibers
with a sparse, patchy distribution of collagen type III, coated with collagen
type IV and laminin. Cell adhesive proteins vitronectin and thrombospondin as
well as proteoglycans (macro molecular components of connective tissue) have
been found in the LC also. Abnormalities of this extracellular matrix may contribute
to glaucomatous damage seen in patients with glaucomatous optic atrophy. LC
cells in glaucomatous eyes also express more profibrotic genes than cells from
normal LC. These differences in the LC extracellular matrix may contribute to
the biochemical properties of the LC.
NERVE
SHEATHS:
A
rim of connective tissue occasionally extends between the choroid and optic
nerve tissues, especially temporally. This is called the border tissue of
Elschnig.
Posterior
to the globe the optic nerve is surrounded by meningeal sheaths (pia, arachnoid
and dura) which consist of connective tissue lined by meningoepithelial cells
or mesothelium.
RETINAL
NERVE FIBER LAYER:
Axons
of the RGC pass to the ONH in a characteristic pattern.
Fibers from the temporal periphery arch above and below the macula and papillomacular bundle as superior and inferior arcuate nerve fibers with a horizontal raphe lying in between. Those from the central retina (known as the papillomacular bundle) and nasal fibers take a more direct path to the ONH. The nasal fibers also form the superior and inferior radiating fibers but without a horizontal raphe dividing them.
Arcuate fibers are the most sensitive to glaucomatous damage. On the temporal side of thefundus, these fibers stop abruptly at the horizontal raphe. Therefore, they produce characteristic nasal step defects in glaucoma. Radiating fibers from the nasal side and more resistant to damage. They also do not stop at the horizontal raphe. Therefore, temporal wedge defects do not respect the horizontal meridian. The most resistant retinal nerve fibers arr those from the macula (papillomacular bundle). Thus, central vision is usually preserved even in advanced glaucoma.
Fibers from the temporal periphery arch above and below the macula and papillomacular bundle as superior and inferior arcuate nerve fibers with a horizontal raphe lying in between. Those from the central retina (known as the papillomacular bundle) and nasal fibers take a more direct path to the ONH. The nasal fibers also form the superior and inferior radiating fibers but without a horizontal raphe dividing them.
Arcuate fibers are the most sensitive to glaucomatous damage. On the temporal side of thefundus, these fibers stop abruptly at the horizontal raphe. Therefore, they produce characteristic nasal step defects in glaucoma. Radiating fibers from the nasal side and more resistant to damage. They also do not stop at the horizontal raphe. Therefore, temporal wedge defects do not respect the horizontal meridian. The most resistant retinal nerve fibers arr those from the macula (papillomacular bundle). Thus, central vision is usually preserved even in advanced glaucoma.
AXONS
IN THE ONH:
The
arcuate nerve fibers occupy the superior and temporal portions of the ONH with
axons from the peripheral retina taking a more peripheral position in the ONH.
The arcuate fibers are the most susceptible to early glaucomatous damage. The
papillomacular fibers pass inferotemporally in the nerve where the axonal
density is high. They intermingle with extramacular fibers, which may explain
the retention of central vision in early glaucomatous optic atrophy.
"Deeper fibers from the peripheral retina occupy a peripheral or superficial location in the ONH. The superficial fibers from the central retina occupy a central or deeper position in the ONH."
The
normal ONH contains 70,000-1.2 million axons, these afferent nerve fibers from the eye carry sensations towards the brain.
ORDER OF VISUAL FIELD DEFECTS APPEARING IN GLAUCOMA
IC BB wings & SAD steps (mnemonic)
IC= Isopter contraction
BB= Baring of blind spot
Wings= wing shaped paracentral scotomas
S= Seidel sickle-shaped scotomas
A= Arcuate scotoma
D= Double arcuate or Ring scotoma
Steps= Roenne's nasal steps ( can appear early or late during the disease)
